解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The proteins of the tumor necrosis factor (TNF) receptor superfamily are a group of cell-surface receptors critically involved in the maintenance of homeostasis of the immune system. By interacting with their corresponding ligands, these receptors either induce cell death or promote cell survival of immune cells. The ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:26:1-3:323
更新日期:2002-01-01 00:00:00
abstract::Experimental autoimmune encephalomyelitis (EAE) is a T cell mediated demyelinating disease of the central nervous system (CNS) that serves as a model for multiple sclerosis (MS). Insights into the pathogenesis of this model may help scientists understand the human disease and aid in rational drug discovery. In this re...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:25:2:167
更新日期:2002-01-01 00:00:00
abstract::Epstein-Barr virus (EBV) is a ubiquitous human gamma-herpesvirus that establishes life-long latency and is associated with lymphoproliferative disorders and the development of several malignancies. EBV infection is frequently, but not always, associated with the development of a syndrome termed infectious mononucleosi...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:25:3:201
更新日期:2002-01-01 00:00:00
abstract::The generation and maintenance of B lymphocytes is controlled by biochemical signals transmitted by the B cell antigen receptor(BCR) complex. These signals are transduced by multiple cytoplasmic protein tyrosine kinases (PTKs) including Lyn, Syk, and Bruton's tyrosine kinase (BTK). Upon BCR engagement, these PTKs acti...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:23:2-3:147
更新日期:2001-01-01 00:00:00
abstract::Our laboratory has studied the role of CD40 ligand (CD40L, CD154) in the primate immune response to allogenic and infectious challenges. We find that intensive early blockade of CD40L reliably attenuates acute rejection of primate cardiac allografts. Monotherapy fails to prevent late graft loss, which often occurs in ...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1385/IR:23:2-3:253
更新日期:2001-01-01 00:00:00
abstract::T helper (Th) lymphocytes differentiate into two distinct subsets--Th1 and Th2--as defined by functional abilities and cytokine profiles. The functional differences between Th subsets are explained primarily through the activities of the cytokines they secrete. Interferon-gamma (IFN-gamma) is the signature cytokine of...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:23:1:59
更新日期:2001-01-01 00:00:00
abstract::Contact hypersensitivity (CHS) is a T cell-mediated immune response to cutaneous sensitization and subsequent challenge with haptens such as dinitrofluorobenzene and oxazolone. Many aspects concerning the development and regulation of CHS remain unknown. Using CHS as a model of T cell-mediated immune responses to anti...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:24:1:69
更新日期:2001-01-01 00:00:00
abstract::An effective host response against viral infection of the central nervous system (CNS) is the principal factor dictating the outcome of infection. It is the responsibility of the immune response to contain and control viral replication. Paradoxically, it is the immune response that may also contribute to the developme...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:24:2:111
更新日期:2001-01-01 00:00:00
abstract::CD27 is a tumor necrosis factor (TNF) receptor family member whose expression is limited to cells of the lymphoid lineage. Constitutively expressed on T lymphocytes, it is a costimulatory molecule for a regulatory subset. Induced on B lymphocytes after antigenic challenge, it is a marker of memory cells. CD70, CD27 li...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:21:1:23
更新日期:2000-01-01 00:00:00
abstract::The participation of inflammatory cells in atherosclerosis is a well-known process that involves numerous molecules including chemotactic cytokines (chemokines) for their entry into the vessel wall. Although the C-C chemokine monocyte chemoattractant protein-1 and its receptor, CCR2, have been implicated in atheroscle...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/ir:21:2-3:129
更新日期:2000-01-01 00:00:00
abstract::The goal of our work is to understand, from the molecular to the organismal level, the principles that drive and sustain lifelong infection by viruses. These infectious agents live in a dynamic equilibrium (homeostasis) with their hosts in which both immune and nonimmune pathways contribute to viral homeostasis. Disru...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:21:2-3:219
更新日期:2000-01-01 00:00:00
abstract::In performing host-defense functions, cells of the immune system become activated by soluble chemokine signals and must migrate through endothelial cell or solid tissue barriers to reach sites of inflammation or infection. Regulated adhesive interactions of immune cells with endothelium, extracellular matrix component...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:21:2-3:293
更新日期:2000-01-01 00:00:00
abstract::The joining of T cell receptor (TCR) and immunoglobulin (Ig) gene segments through the process of V(D)J recombination occurs in a lineage-specific and developmental-stage-specific way during the early stages of lymphocyte development. Such developmental regulation is thought to be mediated through the control of gene ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:22:2-3:127
更新日期:2000-01-01 00:00:00
abstract::The human thymus is required for establishment of a normal T cell repertoire in fetal development, as children born without a thymus (DiGeorge Syndrome) lack thymus-derived (T) and T cell immunity. While the function of the thymus in children for production of new T cells is clear, it has not been obvious that the adu...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:22:2-3:253
更新日期:2000-01-01 00:00:00
abstract::Staphylococcal exotoxins, staphylococcal enterotoxins A-E (SEA-SEE), and toxic shock syndrome toxin- (TSST-1) are potent activators of the immune system and cause a variety of diseases in humans, ranging from food poisoning to shock. These toxins are called superantigens because of their ability to polyclonally activa...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02786471
更新日期:1999-01-01 00:00:00
abstract::Our laboratory has studied the molecular basis of T helper cell differentiation. We have used reporter transgenic mice, selective hybridization techniques, and studies of cell signaling to show that a complex pattern of gene expression is reprogrammed as the decision is made to become either a Th1 or Th2 cell. Many of...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02786484
更新日期:1999-01-01 00:00:00
abstract::The MHC class II antigen processing pathway provides a mechanism to selectively present peptides generated in the endosomal compartments of antigen presenting cells to CD4+ T cells. Transport of newly synthesized class II molecules to the endosomal pathway requires the function of an accessory protein, invariant chain...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02790403
更新日期:1999-01-01 00:00:00
abstract::Host defense of the lung is characterized by a fine balance between the generation of a vigorous inflammatory response to clear pathogens and maintenance of the integrity of the alveolar gas-exchange surface. The magnitude of the inflammatory response is therefore tightly regulated by pro- and anti-inflammatory cytoki...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02786504
更新日期:1999-01-01 00:00:00
abstract::Primary biliary cirrhosis (PBC) is a chronic, progressive cholestatic liver disease, which is invariably fatal. Circumstantial and indirect evidence suggests that autoimmune mechanisms have a role in the pathogenesis of PBC. Antimitochondrial antibodies (AMA) are highly sensitive and specific markers that can predict ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02788754
更新日期:1998-01-01 00:00:00
abstract::The examination of the immune T cell response to herpes simplex virus (HSV) antigen glycoprotein D (gD) in an ongoing infection has revealed a uniquely broad range of antigenic determinants seen. This has been shown in the murine T cell response to gD determinants where over 60% of the overlapping peptides are recogni...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02786433
更新日期:1998-01-01 00:00:00
abstract::The erbB family of receptor tyrosine kinases are growth factor receptors that are overexpressed or mutated in a large variety of human cancers. Studies of erbB-mediated signal transduction will lead to an understanding of the role played by this family of receptors in normal and transformed cells. In this article, we ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02786443
更新日期:1998-01-01 00:00:00
abstract::The initial stages of an immune response are regulated at the level of the cell-surface antigen and Fc receptors. The extracellular portions of these receptors provide immune specificity and determine the nature of the responding effector cells, whereas the intracellular portion transduces signals into the cell and de...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02786325
更新日期:1997-02-01 00:00:00
abstract::Interleukin-2 (IL-2), secreted principally by activated helper T-cells, plays a pivotal role in the generation and regulation of the immune response. The various biologic functions of IL-2 have been the focus of intensive study over the years and have been well worked out. By contrast, an understanding of the intracel...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02786399
更新日期:1997-01-01 00:00:00
abstract::Consideration of the pathophysiology of insulin-dependent diabetes mellitus in the nonobese diabetic (NOD) mouse can be viewed from a temporal perspective. We argue that there are discontinuous phases and each phase may reflect a phenotype educed by a particular set of genetic and epigenetic events. Therefore, tempora...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02786358
更新日期:1997-01-01 00:00:00
abstract::Heat shock proteins (HSPs) are evolutionarily highly conserved polypeptides synthesized by many cells to preserve cellular functions under a variety of stressful conditions including infections. We have investigated the involvement of 65-kDa HSP (HSP65) in host protection against an intracellular protozoan parasite, T...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02918253
更新日期:1996-01-01 00:00:00
abstract::Naive CD4 T cell activation is a complex process involving many steps. T cell receptor (TCR) signals, provided by interaction with peptide/MHC on antigen-presenting cells (APC), control many events associated with activation. The extent of TCR signaling and the magnitude of the T cell response is in turn controlled by...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02918501
更新日期:1996-01-01 00:00:00
abstract::Various multisubunit receptors of the immune system share similarities in structure and induce closely related signal transduction pathways upon ligand binding. Examples include the T cell antigen receptor (TCR), the B cell antigen receptor (BCR), and the high-affinity receptor for immunoglobulin E (Fc epsilon RI). Al...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02918171
更新日期:1995-01-01 00:00:00
abstract::Assembly of the class I MHC molecule is inextricably linked to the antigen presentation function of the class I molecule. Association of the class I MHC molecule with beta 2-microglobulin (beta 2m) is a prerequisite for association with the heterodimeric protein TAP, and once peptide is acquired, the class I molecule ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02918217
更新日期:1995-01-01 00:00:00
abstract::The human mayor histocompatibility complex class I molecule HLA-A2 preferentially binds peptides that contain Leu at P2 and Val or Leu at the C terminus. The other amino acids in the peptide also contribute to binding positively or negatively. It is possible to estimate the binding stability of HLA-A2 complexes contai...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02918496
更新日期:1995-01-01 00:00:00
abstract::Many clues point to a role for T lymphocytes in the pathogenesis of rheumatoid arthritis (RA), although the importance of these cells and their position within the rheumatoid pathogenic scheme remain unknown. Encouraged by data from animal models of T-lymphocyte-mediated autoimmunity, a major focus of research into th...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02918222
更新日期:1994-01-01 00:00:00
abstract::Cytolytic effector function fails to develop if proliferation of allospecific cytolytic T lymphocyte precursors is inhibited, but the requirements for generation of cytolytic activity have not been fully defined. In contrast, the cytolytic effector function of cytolytic T lymphocyte clones does not change during the c...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/BF02935614
更新日期:1994-01-01 00:00:00
abstract::Ethanol addition to B lymphocytes in vitro inhibits antigen-induced antibody secretion and antigen-induced cell proliferation. We tested the hypothesis that ethanol can inhibit the effect of interleukins on B-cell proliferation by adding ethanol to in vitro functional assays for IL-2 and IL-4. Ethanol does not inhibit...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/BF02918616
更新日期:1992-01-01 00:00:00
abstract::CD23, also known as the low affinity receptor for IgE (Fc epsilon RII), belongs to a novel superfamily of type-II integral membrane proteins. Fc epsilon RII expression was originally described on B cells but subsequent studies showed that CD23 is expressed on a variety of hematopoietic cells and is regulated by severa...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02919132
更新日期:1992-01-01 00:00:00
abstract::About one half of circulating human B cells express the Leu-8 peripheral lymph node homing receptor that has been implicated in adhesion of lymphocytes and neutrophils to vascular endothelium. A novel and unique function of the Leu-8 antigen has been found in the present study: anti-Leu-8 monoclonal antibody directly ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/BF02919739
更新日期:1991-01-01 00:00:00
abstract::Morphological data in humans and rodents and functional data of intraepithelial lymphocytes of mice support the idea that cytotoxic cells are a significant population of the human mucosa. Previously it was shown that human IEL have no spontaneous cell-mediated cytotoxicity and that human LPL cells have anti-CD3-mediat...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/BF02919697
更新日期:1991-01-01 00:00:00
abstract::We examine whether B cell lines enriched for DNA specificity from either autoimmune (BWF1) or normal mice (Balb/c) can be rendered unresponsive to autoantigen in terms of the specific suppression of direct antibody-forming cells to DNA. These B cell lines were both Lyt-1 positive and negative. Preincubation with oligo...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/BF02935511
更新日期:1989-01-01 00:00:00
abstract::We have used MAb to L3T4 to examine the function of L3T4+ T cells in normal and autoimmune mice. Treatment of mice with MAb to L3T4 profoundly depleted L3T4+ cells from the blood, spleen, and lymph nodes, but not the thymus. In BALB/c and C57BL/6 mice, selective depletion of L3T4+ cells blocked both primary and second...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/BF02917584
更新日期:1986-01-01 00:00:00